Krzywe dawka-odpowiedź

Chemometria jest bliska farmakokinetyce i odwrotnie, dlatego warto zapoznać się z nowym artykułem dotyczącym matematycznego modelowania krzywych dawka-odpowiedź, z uwzględnieniem dynamiki nieliniowej [1]. Lekturę uzupełniającą zacząłbym od poniższych trzech tekstów (cytowanych w powyższym artykule między innymi pracami) [2][3][4].

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References

  1. J. Gabrielsson, and L.A. Peletier, "Dose–response–time data analysis involving nonlinear dynamics, feedback and delay", European Journal of Pharmaceutical Sciences, vol. 59, pp. 36-48, 2014. http://dx.doi.org/10.1016/j.ejps.2014.04.007
  2. G. Pillai, R. Gieschke, T. Goggin, P. Jacqmin, R.C. Schimmer, and J. Steimer, "A semimechanistic and mechanistic population PK-PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis", British Journal of Clinical Pharmacology, vol. 58, pp. 618-631, 2004. http://dx.doi.org/10.1111/j.1365-2125.2004.02224.x
  3. P. Jacqmin, E. Snoeck, E. van Schaick, R. Gieschke, P. Pillai, J. Steimer, and P. Girard, "Modelling Response Time Profiles in the Absence of Drug Concentrations: Definition and Performance Evaluation of the K–PD Model", Journal of Pharmacokinetics and Pharmacodynamics, vol. 34, pp. 57-85, 2006. http://dx.doi.org/10.1007/s10928-006-9035-z
  4. N.L. Dayneka, V. Garg, and W.J. Jusko, "Comparison of four basic models of indirect pharmacodynamic responses", Journal of Pharmacokinetics and Biopharmaceutics, vol. 21, pp. 457-478, 1993. http://dx.doi.org/10.1007/BF01061691

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